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a_proposal_for_the_study_of_the_role_of_hbx_in_hepatocellular_carcinoma [2014/01/29 15:34]
xeriandros
a_proposal_for_the_study_of_the_role_of_hbx_in_hepatocellular_carcinoma [2018/07/29 01:22] (current)
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 The HBV genome has not been definitively found to possess viral oncogenes; however one proposed mechanism of HBV-induced HCC suggests that viral DNA insertion into the host genome results in activation of cellular oncogenes. This hypothesis is supported by the fact that HBV has been shown to contain an enhancer sequence which is active in integrated HBV DNA in vivo, and insertional activation of mevalonate kinase have been detected in HBV infected cells, demonstrating the potential for transformative effects of insertional activation via HBV [6,7]. Nonetheless,​ insertional activation alone does not account for the high incidence of HCC in HBV infected patients, and in recent years studies have focused on the properties of the HBV X protein (HBx). The HBV genome has not been definitively found to possess viral oncogenes; however one proposed mechanism of HBV-induced HCC suggests that viral DNA insertion into the host genome results in activation of cellular oncogenes. This hypothesis is supported by the fact that HBV has been shown to contain an enhancer sequence which is active in integrated HBV DNA in vivo, and insertional activation of mevalonate kinase have been detected in HBV infected cells, demonstrating the potential for transformative effects of insertional activation via HBV [6,7]. Nonetheless,​ insertional activation alone does not account for the high incidence of HCC in HBV infected patients, and in recent years studies have focused on the properties of the HBV X protein (HBx).
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 HBx was first noted during the nucleotide sequencing of HBV, at which time an open reading frame (ORF) in the viral genome with which no protein or function was formally associated was designated as the X region [8]. Since then, HBx has been identified as a 17kDa protein necessary for successful HBV replication,​ with its nuclear localization being essential to the viral replication process by means of uncertain mechanisms [9]. HBx has been shown to have pleiotropic effects, some of which are suspected to be directly related to hepatocarcinogenesis. ​ HBx was first noted during the nucleotide sequencing of HBV, at which time an open reading frame (ORF) in the viral genome with which no protein or function was formally associated was designated as the X region [8]. Since then, HBx has been identified as a 17kDa protein necessary for successful HBV replication,​ with its nuclear localization being essential to the viral replication process by means of uncertain mechanisms [9]. HBx has been shown to have pleiotropic effects, some of which are suspected to be directly related to hepatocarcinogenesis. ​
  

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